In order to get blueberries goes on sale in advance and obtain greater economic benefits, southern blueberries were moved to an intelligent greenhouse with controllable environment for experimental production. The early maturing production control technology of southern blueberry intelligent greenhouse was explored and studied. First, a detailed and comprehensive investigation and summary were conducted on the production factors of blueberry soilless cultivation, such as the production characteristics of various blueberry varieties, the pH and composition of the substrate, the key points of water and fertilizer irrigation, and the scope of the microenvironment climate. Then, the existing Venlo-type greenhouse was deployed for blueberry production, and the geography, climate and internal structural conditions of the greenhouse were briefly described, and the greenhouse blueberry full-cycle control goal was planned. Finally, the production control system was designed and implemented based on the Internet of Things technology, and the overall framework of the software layer, the hardware layer and the cloud were introduced. Based on multi-factor coordinated control model of greenhouse environment, according to the characteristics of blueberry growth environment, a set of blueberry greenhouse multi-factor coordinated control algorithms were proposed and used for environmental regulation. The experimental greenhouse is located in the southeast of Huaqiao Town, Kunshan city, Suzhou city, Jiangsu province. It has been verified that the overall control system has a significant effect, and the first wave of fruits was harvested in early May 2021, making the southern variety of blueberry enter the fruit picking period nearly one month earlier. Compared with the blueberry plants without cold storage, the yields per plant of "Star" "Emerald" "Lanmei No. 1", and "Coast" after cold storage increased by 51.5%, 85.5%, 43.8%, and 94.7%, respectively, and the weight of each fruit was increased 10.9%, 7.2%, 2.6%, and 5.3%, respectively. Experiments proved that the use of multi-factor coordinated control algorithms for regulation can increase the yield and quality of blueberries and achieve significant economic benefits and provide a demonstration for the industrialization of blueberry plants in southern greenhouses to promote early maturity production and management.